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I recently went back to taking Glucosamine/Chondroitin/MSM because of severe arthritic pain in my left knee that suddenly emerged. (I had stopped taking it about a year ago because of a major study that showed that Glucosamine/Chondroitin/MCM was not effective, but have since learned that this study was funded by Celebrex...anyway, that is another story.)
I had been taking another Glucosamine supplement for about two months, as well as using Penetrex as a topical anti-inflammatory and doing PT exercises. My knee pain had lessened substantially. However, when I shifted to the Osteo Bi-Flex, my knee pain pretty much completely vanished...within three days! At first, I couldn't figure out what could have caused the improvement, but the only change I had made was shifting to the Osteo Bi-Flex, so I have to think that it made a real difference and surprisingly quickly. I'm definitely going to continue taking this indefinitely to hang on to the cartilage I have left. My orthopedic specialist says that Glucosamine effects are the placebo effect, but I don't think so. (Maybe he is receiving gifts from Celebrex). However, if this is the placebo effect, I'm all for it...no pain and no side effects (that I know of).